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基于DNA鏈置換的兩位格雷碼減法器分子電路設(shè)計

王延峰,  張楨楨,  王盼如,  孫軍偉

王延峰, 張楨楨, 王盼如, 孫軍偉. 基于DNA鏈置換的兩位格雷碼減法器分子電路設(shè)計[J]. 電子與信息學(xué)報, 2020, 42(10): 2557-2565. doi: 10.11999/JEIT190880
引用本文: 王延峰, 張楨楨, 王盼如, 孫軍偉. 基于DNA鏈置換的兩位格雷碼減法器分子電路設(shè)計[J]. 電子與信息學(xué)報, 2020, 42(10): 2557-2565. doi: 10.11999/JEIT190880
Yanfeng WANG, Zhenzhen ZHANG, Panru WANG, Junwei SUN. Molecular Circuit Design of Two-bit Gray Code Subtracter Based on DNA Strand Displacement[J]. Journal of Electronics & Information Technology, 2020, 42(10): 2557-2565. doi: 10.11999/JEIT190880
Citation: Yanfeng WANG, Zhenzhen ZHANG, Panru WANG, Junwei SUN. Molecular Circuit Design of Two-bit Gray Code Subtracter Based on DNA Strand Displacement[J]. Journal of Electronics & Information Technology, 2020, 42(10): 2557-2565. doi: 10.11999/JEIT190880

基于DNA鏈置換的兩位格雷碼減法器分子電路設(shè)計

doi: 10.11999/JEIT190880

  • 鄭州輕工業(yè)大學(xué)電氣信息工程學(xué)院 鄭州 450002

基金項目: 國家重點研發(fā)計劃中美政府間合作項目(2017YFE0103900)，國家自然科學(xué)基金河南聯(lián)合基金(U1804262)，國家自然科學(xué)基金重點項目(61632002)，中原千人計劃(204200510003)，食管癌防治國家重點實驗室開放基金(K2020-0010, K2020-0011)
詳細(xì)信息
    作者簡介:

    王延峰：男，1973年生，教授，研究方向為生物啟發(fā)計算

    張楨楨：女，1994年生，碩士生，研究方向為生物啟發(fā)計算

    王盼如：女，1994年生，博士生，研究方向為生物啟發(fā)計算

    孫軍偉：男，1984年生，副教授，研究方向為生物啟發(fā)計算

    通訊作者:

    孫軍偉　junweisun@yeah.net

  • 中圖分類號: TP 301

Molecular Circuit Design of Two-bit Gray Code Subtracter Based on DNA Strand Displacement

  • School of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China

Funds: The National Key R and D Program of China for International S and T Cooperation Projects (2017YFE0103900), The Joint Funds of the National Natural Science Foundation of China (U1804262), The State Key Program of National Natural Science of China (61632002), The Central Plains Thousand Talents Program (204200510003), The Open Fund of State Key Laboratory of Esophageal Cancer Prevention and Treatment (K2020-0010, K2020-0011)
  • 摘要: DNA鏈置換技術(shù)具有自發(fā)性、并行性、可編程性、動態(tài)級聯(lián)性的特點，在DNA計算中占據(jù)重要的地位。DNA鏈置換技術(shù)被廣泛的應(yīng)用于解決數(shù)學(xué)問題，該文采用格雷碼編碼方式結(jié)合DNA鏈置換技術(shù)設(shè)計了兩位減法器，擴(kuò)展DNA減法運(yùn)算。最后利用Visual DSD軟件模擬兩位減法器，該電路達(dá)到預(yù)期的功能，且具有并行性和可擴(kuò)展性，可與其他生化電路結(jié)合使用。
    Abstract: DNA strand displacement technology has the characteristics of spontaneity, parallelism, programmability and dynamic cascade, which is widely used to solve mathematical problems. In this paper, a two-bit subtracter is designed by using Gray code encoding and DNA strand displacement technology to extend the operation of DNA subtraction. Finally, Visual DSD software is used to simulate the two-bit subtracter. The circuit, with the strong parallelism and expansibility, achieves the expected function. It can be used in combination with other biochemical circuits.
    • HTML全文

  • 圖  1  DNA鏈置換反應(yīng)的過程機(jī)理

    圖  2  兩位格雷碼減法器seesaw門

    圖  3  兩位減法器seesaw雙軌分子電路

    圖  4  DNA鏈置換的反應(yīng)過程機(jī)理示意圖

    5  兩位格雷碼減法器仿真圖

    表  1  兩位減法器操作運(yùn)算的真值表

    X2X1/減數(shù)U2U1/被減數(shù)S2S1/差值B2/高位借位X2X1/減數(shù)U2U1/被減數(shù)S2S1/差值B2/高位借位
    00000001100110
    00011011101010
    00111111111000
    00100111110101
    01000101000100
    01010001001110
    01111011011010
    01101111010000
    下載: 導(dǎo)出CSV
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出版歷程
  • 收稿日期:  2019-11-04
  • 修回日期:  2020-06-07
  • 網(wǎng)絡(luò)出版日期:  2020-07-11
  • 刊出日期:  2020-10-13

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