四線渦輪式慢阻肺健康監(jiān)護系統(tǒng)研究

趙榮建; 周旺; 湯敏芳; 陳賢祥; 杜利東; 趙湛; 楊汀; 詹慶元; 方震

doi:10.11999/JEIT180315

四線渦輪式慢阻肺健康監(jiān)護系統(tǒng)研究

doi: 10.11999/JEIT180315

趙榮建^{1, 2},
周旺^{1, 2},
湯敏芳^{1, 2},
陳賢祥¹,
杜利東¹,
趙湛^{1, 2},
楊汀³,
詹慶元³,
方震^{1, 2, ,}

1.
中國科學(xué)院電子學(xué)研究所傳感技術(shù)國家重點實驗室 ??北京 ??100190
2.
中國科學(xué)院大學(xué) ??北京 ??100049
3.
中日友好醫(yī)院 ??北京 ??100029

基金項目: 北京市自然科學(xué)基金(Z16003)，國家重點研發(fā)計劃(2016YFC1304302)

詳細信息

作者簡介:
趙榮建：男，1985年生，博士生，研究方向為生命信息感知技術(shù)

周旺：男，1992年生，碩士生，研究方向為可穿戴式醫(yī)療檢測技術(shù)

湯敏芳：女，1996年生，博士生，研究方向為可穿戴式醫(yī)療檢測技術(shù)

陳賢祥：男，1979年生，副研究員，碩士生導(dǎo)師，研究方向為可穿戴式醫(yī)療檢測技術(shù)

杜利東：男，1981年生，助理研究員，研究方向為微納制造技術(shù)

趙湛：男，1958年生，研究員，博士生導(dǎo)師，研究方向為微納制造技術(shù)、無線傳感器網(wǎng)絡(luò)、生命信息感知與計算

楊?。号?，1968年生，主任醫(yī)師，博士生導(dǎo)師，研究方向為呼吸與危重癥醫(yī)學(xué)

詹慶元：男，1970年生，主任醫(yī)師，博士生導(dǎo)師，研究方向為呼吸與危重癥醫(yī)學(xué)

方震：男，1976年生，研究員，博士生導(dǎo)師，研究方向為可穿戴式醫(yī)療檢測技術(shù)

通訊作者:
方震　zfang@mail.ie.ac.cn

中圖分類號: TP389.1; Q819
計量
- 文章訪問數(shù): 1605
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- 被引次數(shù): 0
出版歷程
- 收稿日期: 2018-04-03
- 修回日期: 2018-08-14
- 網(wǎng)絡(luò)出版日期: 2018-09-13
- 刊出日期: 2019-02-01

Research of Chronic Obstructive Pulmonary Disease Monitoring System Based on Four-line Turbine-type

Rongjian ZHAO^{1, 2},
Wang ZHOU^{1, 2},
Minfang TANG^{1, 2},
Xianxiang CHEN¹,
Lidong DU¹,
Zhan ZHAO^{1, 2},
Ting YANF³,
Qingyuan ZHAN³,
Zhen FANG^{1, 2
, ,}

1.
State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China
2.
University of Chinese Academy of Sciences, Beijing 100049, China
3.
China-Japan Friendship Hospital, Beijing 100029, China

Funds: The Key Project of Beijing Municipal Natural Science Foundation (Z16003), The National Key Research and Development Project (2016YFC1304302)

摘要

摘要:
針對傳統(tǒng)渦輪式肺活量計存在檢測精度不高、可靠性差的問題，該文提出一種新穎的四線渦輪式檢測方法，研制了一款高精度、高可靠性的慢阻肺監(jiān)護系統(tǒng)。在硬件上，根據(jù)四線渦輪式檢測方法設(shè)計了四線式呼氣采集電路，提高了光路接收分辨率，并通過合理的元器件布置，減少了發(fā)光-光敏二極管相互間串?dāng)_，提高了系統(tǒng)的可靠性；在軟件上，采用線性回歸算法對其脈沖計數(shù)與分析得到用力肺活量、峰值流速等早期篩查與診斷指標。該系統(tǒng)利用標準Fluke氣流分析儀的進行了數(shù)據(jù)標定，與傳統(tǒng)醫(yī)用渦輪式肺功能儀測試對比：用力肺活量平均相對誤差由1.98%降低至1.47%；峰值流速平均相對誤差由2.04%降低至1.02%。實驗表明，四線渦輪式慢阻肺監(jiān)護系統(tǒng)的呼氣指標比傳統(tǒng)慢阻肺系統(tǒng)檢測精度更高，可靠性更好，適用于慢阻肺疾病的早期篩查與精準診斷，結(jié)合血氧飽和度、呼氣末二氧化碳等指標，能實現(xiàn)對慢阻肺患者的醫(yī)療監(jiān)護，特別對于中度和重度慢阻肺患者能起到預(yù)警和控制病情的作用。
- 四線渦輪式 /
- 慢阻肺 /
- 用力肺活量 /
- 峰值流速
Abstract:
To improve accuracy and reliability of the traditional turbine-vital capacity meter, a novel four-line turbine-detection method is presented for the high precision and high reliability Chronic Obstructive Pulmonary Disease (COPD) monitoring system. On the hardware, a four-line breath signal acquisition circuit is designed following the four-line turbine-type detection method, which improves the resolution of the optical path through reasonable components arrangement. On the software, a linear regression algorithm is used to obtain early screening and diagnostic indicators such as Forced Vital Capacity (FVC), Peak Expiratory Flow (PEF) and so on. The standard Fluke air flow analyzer is used for data calibration, compared with the traditional medical turbine-type lung function meter: FVC average relative error is reduced from 1.98% to 1.47% and PEF average relative error is reduced from 2.04% to 1.02%. It is showed that the expiratory parameters of the four-line turbine-type COPD monitoring system is more accurate and reliable than that of the traditional COPD system which is suitable for early screening and accurate diagnosis of COPD. Combined with pulse oxygen saturation, End-tidal CO2, it can be used to achieve the medical care for COPD and play an important role to early detect and control of disease for moderate or severe COPD patients.
- Four-line turbine-type /
- Chronic Obstructive Pulmonary Disease (COPD) /
- Forced Vital Capacity (FVC) /
- Peak Expiratory Flow (PEF)

HTML全文

圖 1 呼氣信號采集原理圖

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圖 2 系統(tǒng)結(jié)構(gòu)框圖

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圖 3 采用傳統(tǒng)方法與四線式方法二極管分布示意圖

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圖 4 四線式方法二極管光路分布示意圖

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圖 5 呼氣信號采集電路圖

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圖 6 在不同轉(zhuǎn)速下呼氣信號采集的波形圖

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圖 7 原型機照片

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圖 8 FVC測量相關(guān)系數(shù)圖和測量Bland–Altman圖

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圖 9 PEF測量相關(guān)系數(shù)圖和測量Bland–Altman圖

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圖 10 四線渦輪式檢測方法與二線渦輪式檢測方法誤差對比圖

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圖 11 四線渦輪式慢阻肺設(shè)備與醫(yī)用慢阻肺設(shè)備誤差對比

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