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基于阻抗檢測微傳感技術(shù)的皮膚滲透性評估方法

趙湛,  盧飛,  王辰碩,  趙榮建,  杜利東,  方震

趙湛, 盧飛, 王辰碩, 趙榮建, 杜利東, 方震. 基于阻抗檢測微傳感技術(shù)的皮膚滲透性評估方法[J]. 電子與信息學(xué)報, 2018, 40(8): 1927-1933. doi: 10.11999/JEIT171242
引用本文: 趙湛, 盧飛, 王辰碩, 趙榮建, 杜利東, 方震. 基于阻抗檢測微傳感技術(shù)的皮膚滲透性評估方法[J]. 電子與信息學(xué)報, 2018, 40(8): 1927-1933. doi: 10.11999/JEIT171242
ZHAO Zhan, LU Fei, WANG Chenshuo, ZHAO Rongjian, DU Lidong, FANG Zhen. Evaluation of Skin Permeability Based on Impedance Detection by Microsensor Technology[J]. Journal of Electronics & Information Technology, 2018, 40(8): 1927-1933. doi: 10.11999/JEIT171242
Citation: ZHAO Zhan, LU Fei, WANG Chenshuo, ZHAO Rongjian, DU Lidong, FANG Zhen. Evaluation of Skin Permeability Based on Impedance Detection by Microsensor Technology[J]. Journal of Electronics & Information Technology, 2018, 40(8): 1927-1933. doi: 10.11999/JEIT171242

基于阻抗檢測微傳感技術(shù)的皮膚滲透性評估方法

doi: 10.11999/JEIT171242

  • (中國科學(xué)院電子學(xué)研究所 北京 100190) ②(中國科學(xué)院大學(xué) 北京 100049)

基金項目: 

國家自然科學(xué)基金(61431019)，北京市自然科學(xué)基金(Z160002)

Evaluation of Skin Permeability Based on Impedance Detection by Microsensor Technology

  • (Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China)

Funds: 

The National Natural Science Foundation of China (61431019), The Key Project of Beijing Municipal Natural Science Foundation (Z160002)

  • 摘要: 基于宏電極的單頻皮膚阻抗測量是利用阻抗進行皮膚滲透性研究的傳統(tǒng)方法之一，其存在誤差大、靈敏度低且不易于設(shè)備集成的缺點。由此，該文通過分析皮膚的分層生理結(jié)構(gòu)以及皮膚滲透性與角質(zhì)層(SC)阻抗的關(guān)系，設(shè)計了基于柔性非對稱叉指微電極的皮膚阻抗傳感器，構(gòu)建了RCW分層阻抗模型，實現(xiàn)了對人體角質(zhì)層阻抗的檢測分析。實驗結(jié)果表明，傳感器輸出的阻抗模值 和 模型擬合參數(shù)可用作表征皮膚滲透性的重要指標(biāo)。該方法可用于區(qū)分不同個體的皮膚滲透性，為人體生理生化檢測相關(guān)的可穿戴設(shè)備參數(shù)調(diào)節(jié)提供依據(jù)。
    Abstract: Traditionally, skin permeability evaluation, which is realized by impedance detected at a certain frequency based on macro electrodes, has the disadvantages of large measurement error, low sensitivity and difficulty in integration. In order to resolve this problem, a flexible non-symmetric interdigital microsensor is designed by analyzing the layered structure of skin and the relationship between skin permeability and impedance of Stratum Corneum(SC). The impedance of SC is measured and analyzed based on the RCW-layered impedance model. It is illustrated that the impedance magnitude of microsensor output and model fitting parameters can be used as the important indicators to evaluate skin permeability. It is proved that the developed sensor can be applied to distinguishing the different individuals skin permeability, and it strongly supports the adjustment of wearable devices related to human physiological and biochemical detection.
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出版歷程
  • 收稿日期:  2017-12-28
  • 修回日期:  2018-03-15
  • 刊出日期:  2018-08-19

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